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Oral sex is not necessarily an effective method of preventing sexually transmitted infections (STIs), although some forms of STIs are believed to be less commonly spread in this way, and oral sex has been recommended as a form of safe sex.but using a real dental dam is seen as preferable; this is because real dental dams cover a larger area, avoid accidents caused by "slipping" outside the covered area, and avoid the risk that makeshift versions may be accidentally damaged or poked with the scissors during the cutting procedure.Such contact can also lead to more mundane infections from common bacteria and viruses found in, around and secreted from the genital regions.

The Centers for Disease Control and Prevention (CDC) stated in 2009: "Studies indicate that oral sex is commonly practiced by sexually active male-female and same-gender couples of various ages, including adolescents." Any sexual exchange of bodily fluids with a person infected with HIV, the virus that causes AIDS, poses a risk of infection.

Risk of STI infection, however, is generally considered significantly lower for oral sex than for vaginal or anal sex, with HIV transmission considered the lowest risk with regard to oral sex.

The study found that 36 percent of the cancer patients had HPV compared to only 1 percent of the healthy control group.

Another study in The New England Journal of Medicine suggests a correlation between oral sex and throat cancer.

Plastic wrap may also be used as a barrier during oral sex, but there exists no conclusive scientific research regarding how effective it may or may not be at preventing disease transmission.

Certain kinds of plastic wrap are manufactured to be microwaveable and are designed to have pores that open when heated, but there also exists no scientific research on what effect, if any, this has on disease transmission when used during oral sex.

Links have been reported between oral sex and oral cancer with human papillomavirus (HPV)-infected people.

In 2005, a research study at Malmö University's Faculty of Odontology suggested that performing unprotected oral sex on a person infected with HPV might increase the risk of oral cancer.

Some people complain that the thickness of the plastic dulls sensation.

A report issued in September 2005 by the National Center for Health Statistics was the basis of an article in the September 26, 2005 issue of Time magazine.

An act of group sex restricted to one woman giving oral sex to several men is referred to as a gangsuck, blowbang or lineup, all derivatives of the slang term gang bang for group sex. Oral sex is commonly used as a means of preserving virginity, especially among heterosexual pairings; this is sometimes termed technical virginity (which additionally includes anal sex, mutual masturbation and other non-penetrative sex acts, but excludes penile-vaginal sex).

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